Idiopathic childhood stroke is associated with human leukocyte antigen (HLA)-B51.
case_series · Level IV
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- Record sourced from PubMed, PMID 1514780.
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Abstract
We report four children with idiopathic stroke syndromes who were assayed for human leukocyte antigen (HLA) class I markers and found to have HLA-B51 in common. This finding suggests that there may be a genetic predisposition for "idiopathic" childhood stroke, and host factors, possibly in concert with environmental factors or viruses, may play a major role in the mechanism of unexplained occlusion of the cerebral vasculature in children.
Medical subject headings
- Cerebrovascular Disorders
- Genes, MHC Class I
- HLA-B Antigens