Cholesterol and APOE genotype interact to influence Alzheimer disease progression.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 15159498.
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Abstract
In this retrospective analysis of 443 Alzheimer disease (AD) patients from a 30-week tacrine trial, change in Alzheimer's Disease Assessment Scale score from baseline to final value was significantly associated with a total serum cholesterol/APOE genotype interaction. Disease progression in the no-APOE epsilon4 allele/high-cholesterol subgroup was greater than in the normal-cholesterol subgroups with or without epsilon4. Cholesterol levels and APOE genotype may interact to affect AD progression. The results are consistent with preclinical data on cholesterol's effects in AD.
Medical subject headings
- Alzheimer Disease
- Apolipoproteins E
- Cholesterol
- Hyperlipoproteinemia Type II