Progressive myopathy with circulating autoantibody against giantin in the Golgi apparatus.
case_report · Level V
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- Record sourced from PubMed, PMID 15159505.
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Abstract
A woman aged 59 years with adult-onset progressive myopathy had anti-Golgi (giantin) autoantibody in the serum. Limb-muscle biopsy revealed chronic myopathy with paucity of cellular reactions and reduced immunostaining for alpha-dystroglycan. The similarity of the current patient with cases of hereditary alpha-dystroglycanopathies (Fukuyama-type congenital muscular dystrophy, Walker-Warburg syndrome, muscle-eye-brain disease, congenital muscular dystrophy type 1C, and limb-girdle muscular dystrophy type 2I) suggests that the Golgi apparatus is the target organelle in a subset of myopathies.
Medical subject headings
- Autoantibodies
- Autoantigens
- Autoimmune Diseases
- Muscular Disorders, Atrophic
- Ribonucleases