The role of gastric stasis in tumor-induced anorexia in rats.
basic_science · Level V
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- Record sourced from PubMed, PMID 1516012.
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Abstract
The current study was undertaken to determine if changes in gastric emptying contribute to tumor-induced anorexia. Rats were implanted with the Walker 256 carcinoma, and food intake was measured daily. On days 0, 8, and 15, the rats were fasted overnight, gavage fed a bolus of liquid food, and residual gastric contents were measured 3 hours later. Tumor growth was associated with a progressive decline in voluntary food intake. When the rats were gavage fed 2.5 or 7 ml of liquid food, the percent of gastric contents cleared in 3 hours was unchanged with tumor growth. Changes in gastric emptying did not contribute to decreased food intake with growth of the Walker 256 in rats.
Medical subject headings
- Anorexia
- Carcinoma 256, Walker
- Gastric Emptying