Checkpoint adaptation; molecular mechanisms uncovered.

Lupardus, Patrick J; Cimprich, Karlene A · Cell · 2004

review · Level V

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Abstract

Adaptation to the DNA damage checkpoint is a phenomenon long thought to be confined to the unicellular world. A new report in this issue of Cell by suggests the presence of a checkpoint adaptation pathway in Xenopus egg extracts that displays interesting molecular parallels to adaptation in yeast.

Medical subject headings