A concise, total synthesis of the TMC-95A/B proteasome inhibitors.
basic_science · Level V
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- Record sourced from PubMed, PMID 15163792.
- Also identified by PMC identifier 514414.
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Abstract
A concise, total synthesis of the proteasome inhibitors TMC-95A/B has been accomplished. The synthesis features the use of an L-serine-derived E-selective modified Julia olefination reaction to ultimately control the stereochemical outcome of the highly oxidized tryptophan fragment. Additionally, the limited use of protecting groups at a late stage of the total synthesis allowed for its completion in an efficient manner.
Medical subject headings
- Multienzyme Complexes
- Peptides, Cyclic
- Protease Inhibitors