CD8+ T cell cross-priming via transfer of proteasome substrates.
basic_science · Level V
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Abstract
"Cross-priming" describes the activation of naïve CD8+ T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from "donor" cells. Antigen transfer is believed to be mediated by donor cell-derived molecular chaperones bearing short peptide ligands generated by proteasome degradation of protein antigens. We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8+ T cell responses.
Medical subject headings
- Acetylcysteine
- Antigen Presentation
- Antigens
- CD8-Positive T-Lymphocytes
- Cross-Priming
- Cysteine Endopeptidases
- Multienzyme Complexes