Inhibit GSK-3beta or there's heartbreak dead ahead.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 15173876.
- Also identified by PMC identifier 419495.
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Abstract
Numerous signaling pathways have been shown to mediate cardioprotection, but the end effectors that mediate protection are only beginning to be elucidated. Numerous cardioprotective drugs are shown to converge on glycogen synthase kinase-3beta (GSK-3beta). The phosphorylation and inhibition of GSK-3beta lead to inhibition or delayed activation of the mitochondrial permeability transition, a key regulator of apoptosis.
Medical subject headings
- Glycogen Synthase Kinase 3