Effect of ultrasound on acute inflammation of transected medial collateral ligaments.
basic_science · Level V
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Abstract
To evaluate the effect of therapeutic ultrasound on the acute inflammation of soft-tissue injuries by measuring the levels of prostaglandin E(2) (PGE(2)) and leukotriene B(4) (LTB(4)). Randomized, case-control study. Laboratory animal facility. Thirty 3-month-old male Sprague-Dawley rats. Rats with medial collateral ligament transection were given 5 minutes of pulsed ultrasound therapy (1:4) daily, with different durations (1, 5, 10d) and intensities (0, 0.5, 1.5, 2.3W/cm(2)). Levels of PGE(2) and LTB(4). The levels of PGE(2) and LTB(4) were higher in all intensity subgroups that received 2.3W/cm(2) intensity on postinjury day 2. On postinjury day 11, LTB(4) was significantly decreased, but PGE(2) was significantly increased. Pulsed ultrasound therapy may stimulate inflammation of acute ligament injury.
Medical subject headings
- Inflammation
- Medial Collateral Ligament, Knee
- Ultrasonic Therapy
Anatomy
- knee