APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42.
cross_sectional · Level IV
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Abstract
The epsilon4 allele of APOE is a risk factor for Alzheimer disease (AD). By analysis of a large cohort of AD patients (n = 563) and control subjects (n = 118), it is shown that the epsilon4 allele is strongly associated with reduced CSF levels of beta-amyloid (1-42) (Abeta42) in both AD (p < 10(-9)) and control (p = 0.0012) populations. As no associations of APOE variants with other indexes of AD severity were observed, this effect may reflect a fundamental involvement of ApoE in Abeta metabolism.
Medical subject headings
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoproteins E
- Peptide Fragments