Birth prevalence of homocystinuria.

Refsum, Helga; Fredriksen, Ase; Meyer, Klaus; Ueland, Per M; Kase, Bengt Frode · J Pediatr · 2004

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Abstract

Serious complications of homocystinuria caused by cystathionine beta-synthase deficiency can be prevented by early intervention. We determined the prevalence of 6 specific mutations in 1133 newborn blood samples. Our results suggest that homocystinuria is more common than previously reported. Newborn screening for homocystinuria through mutation detection should be further considered.

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