Poliovirus proves IRES-istible in vivo.
editorial · Level V
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- Record sourced from PubMed, PMID 15199401.
- Also identified by PMC identifier 420512.
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Abstract
The genetic basis for the attenuation of polio vaccines has been known since the 1980s. Changes in the internal ribosome entry site, within the 5' noncoding region of genomic RNAs, were presumed to reduce translation in certain target organs, leading to the conclusion that attenuation is mediated at the level of translation. A report in this issue of the JCI reveals that poliovirus tropism is, in part, determined after internal ribosome entry.
Medical subject headings
- 5' Untranslated Regions
- Poliovirus
- Poliovirus Vaccines
- Protein Biosynthesis
- Regulatory Sequences, Nucleic Acid
- Ribosomes