Open-label dose-escalation study of oral 1-octanol in patients with essential tremor.
case_series · Level IV
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Abstract
Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.
Medical subject headings
- 1-Octanol
- Drugs, Investigational
- Essential Tremor