Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 15216475.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Virus-specific nasal immunoglobulin (Ig) A and serum antibody titers in 67 respiratory syncytial virus (RSV)-infected adults were compared with titers in age-matched uninfected control subjects. Control subjects had significantly higher levels of nasal IgA and serum IgG to the RSV F, Ga, and Gb proteins than infected subjects. Serum neutralizing-antibody titers to group A and B RSV strains were also lower in infected subjects, although differences were not as large. Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection.
Medical subject headings
- Antibodies, Viral
- Respiratory Syncytial Virus Infections
- Respiratory Syncytial Viruses