The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.
basic_science · Level V
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- Record sourced from PubMed, PMID 15226503.
- Also identified by PMC identifier 454156.
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Abstract
The important anticancer drug Taxol (paclitaxel) binds to tubulin in a stoichiometric ratio and promotes its assembly into microtubules. The conformation of microtubule-bound drug has been the subject of intense study, and various suggestions have been made. In this work we present experimental and theoretical evidence that Taxol adopts a T-shaped conformation when it is bound to tubulin.
Medical subject headings
- Paclitaxel
- Tubulin