Synthesis of the thapsigargins.
basic_science · Level V
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- Record sourced from PubMed, PMID 15226504.
- Also identified by PMC identifier 514437.
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Abstract
The thapsigargins are a family of complex guaianolides with potent and selective Ca(2+)-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.
Medical subject headings
- Thapsigargin