Lack of a fusion requirement for development of bone marrow-derived epithelia.
basic_science · Level V
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Abstract
Analysis of developmental plasticity of bone marrow-derived cells (BMDCs) is complicated by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop from BMDCs without cell-cell fusion. We use the Cre/lox system together with beta-galactosidase and enhanced green fluorescent protein expression in transgenic mice to identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell fusion.
Medical subject headings
- Bone Marrow Cells
- Bone Marrow Transplantation
- Cell Fusion
- Epithelial Cells
- Stem Cells