Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity.
basic_science · Level V
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Abstract
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
Medical subject headings
- Corneal Transplantation
- Gene Expression Regulation
- Hypersensitivity, Delayed
- Keratitis
- Lymphangiogenesis
- Signal Transduction
- Vascular Endothelial Growth Factor Receptor-3