Airway eicosanoids in acute severe respiratory syncytial virus bronchiolitis.
prospective_cohort · Level II
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Abstract
We prospectively studied the levels of eicosanoids in intubated patients with severe bronchiolitis and compared them to electively intubated non-infected infants. LeukotrieneE(4) (LTE(4)), leukotrieneB(4) (LTB(4)), and prostaglandinE(2) (PGE(2)) levels were significantly increased (P <.01) from endotracheal (ET) aspirates of infants with bronchiolitis compared with controls, as were urinary LTE(4) levels (P <.001). We conclude that eicosanoids are increased in the tracheal aspirates and urine of children with bronchiolitis.
Medical subject headings
- Bronchiolitis, Viral
- Dinoprostone
- Leukotriene B4
- Leukotriene E4
- Respiratory Syncytial Virus Infections