Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis.
case_report · Level V
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Abstract
Mastocytosis may be associated with clonal nonmast cell lineage hematologic diseases, including myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Here we present a patient with the simultaneous diagnosis of mastocytosis and an acute myeloid leukemia, M2 subtype in the French-American-British classification, with t(8;21) carrying a population of immature mast cell precursors, and discuss this presentation in the context of a potential pathogenetic cellular link between this leukemia and mastocytosis.
Medical subject headings
- Leukemia, Myeloid, Acute
- Mastocytosis, Systemic