Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.
basic_science · Level V
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Abstract
The tumor suppressor and transcriptional regulator p53 is perhaps one of the most regulated proteins in the cell nucleus and is acted upon by a variety of protein kinases, acetylases, ubiqutin ligases and hydrolases, and SUMO-conjugating enzymes. Now new work suggests a role for an additional modification-neddylation-in negative regulation of p53 transcriptional activity.
Medical subject headings
- Ligases
- Nuclear Proteins
- Proto-Oncogene Proteins
- Tumor Suppressor Protein p53
- Ubiquitin