Localized linear IgA disease induced by ampicillin/sulbactam.
case_report · Level V
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- Record sourced from PubMed, PMID 15243532.
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Abstract
We describe a patient who developed an exclusively perianal-intergluteal vesicular eruption after receiving a course of ampicillin/sulbactam. Direct immunofluorescence microscopy of perilesional skin demonstrated linear deposits of IgA along the dermal-epidermal junction. Circulating IgA autoantibodies against the 120-kd soluble ectodomain of bullous pemphigoid antigen 180 (LAD-1 autoantigen) were detected by immunoblotting. Discontinuation of the antibiotics resulted in a rapid resolution of the skin lesions. This is a most unusual case of localized drug-induced linear IgA disease.
Medical subject headings
- Ampicillin
- Anti-Bacterial Agents
- Autoantigens
- Autoimmune Diseases
- Drug Eruptions
- Immunoglobulin A
- Skin Diseases, Vesiculobullous
- Sulbactam