L-dopa-induced dyskinesia improvement after STN-DBS depends upon medication reduction.
case_series · Level IV
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Abstract
The authors studied the long-term evolution of levodopa-induced dyskinesia (LID) after levodopa challenge in two groups of six STN-deep brain stimulation-treated Parkinson disease (PD) patients, one requiring medication after surgery and the other not. A dramatic (96%) reduction of LID severity was obtained in the six postoperatively untreated patients compared to a moderate improvement (47%) in the treated group (p < 0.03). These data support dopaminergic stimulation and striatal desensitization as major determinants of LID in PD.
Medical subject headings
- Antiparkinson Agents
- Deep Brain Stimulation
- Dyskinesia, Drug-Induced
- Levodopa
- Parkinson Disease