Three-dimensional proton spectroscopy of deep gray matter nuclei in relapsing-remitting MS.
cross_sectional · Level IV
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Abstract
The metabolic changes in the deep gray matter (GM) nuclei, thalamus, and basal ganglia of patients with relapsing-remitting multiple sclerosis were investigated with quantitative, multivoxel, three-dimensional proton MR spectroscopy. This technique facilitated the study of several bilateral structures in a single session at sub-cubic centimeter spatial resolution. Compared with 9 matched control subjects, the deep GM nuclei of 11 patients showed 7% lower N-acetylaspartate and 14% higher choline levels (p = 0.02 for both).
Medical subject headings
- Aspartic Acid
- Basal Ganglia
- Imaging, Three-Dimensional
- Multiple Sclerosis, Relapsing-Remitting
- Nuclear Magnetic Resonance, Biomolecular
- Thalamic Nuclei