Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population.
case_control · Level III
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Abstract
The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD patients without the APOE epsilon4 allele.
Medical subject headings
- Alzheimer Disease
- Membrane Glycoproteins
- Polymorphism, Single Nucleotide