Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C.
basic_science · Level V
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- Record sourced from PubMed, PMID 15249664.
- Also identified by PMC identifier 489981.
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Abstract
Persistently activated Stat3 is found in many different cancers, including approximately 60% of breast tumors. Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9). By immunohistochemical analysis, we observe a positive correlation between strong MMP-9 expression and tyrosine phosphorylated Stat3 in primary breast cancer specimens. These results demonstrate a relationship between activated Stat3 and MMP-9 in breast oncogenesis.
Medical subject headings
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Epithelial Cells
- Mammary Glands, Human
- Matrix Metalloproteinase 9
- Trans-Activators