Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis.
editorial · Level V
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- Record sourced from PubMed, PMID 15254582.
- Also identified by PMC identifier 449755.
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Abstract
New data support the importance of the innate immune response in the resolution or progression of pulmonary fibrosis. The presence of CXC chemokine receptor 3-expressing cells, specifically pulmonary NK cells, is necessary to produce IFN-gamma. This is critical in the polarization of the immune response to injury toward a favorable Th1 response and resolution. In contrast, a Th2 response is associated with progressive fibrosis.
Medical subject headings
- Cytokines
- Immunity, Innate
- Pulmonary Fibrosis