Regulation of WASP: PIP2 Pipped by Toca-1?
editorial · Level V
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Abstract
Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.
Medical subject headings
- Actins
- Cell Movement
- Phosphatidylinositol 4,5-Diphosphate
- Proteins
- cdc42 GTP-Binding Protein