Going the distance, or not, with neurotrophin signals.
basic_science · Level V
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- Record sourced from PubMed, PMID 15260984.
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Abstract
NGF and NT-3 both signal through TrkA receptors on the axons of developing sympathetic neurons, but while NGF supports survival and differentiation, NT-3 does not. In this issue of Cell, the difference is explained as the ability of NGF, but not NT-3, to induce internalization and retrograde transport of activated TrkA.
Medical subject headings
- Cell Differentiation
- Nerve Growth Factor
- Nervous System
- Neurons
- Neurotrophin 3
- Receptor, trkA