Polycystins: from mechanosensation to gene regulation.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 15260985.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Polycystin proteins have been suggested to form mechanosensory transduction complexes involved in a variety of biological functions including sperm fertilization, mating behavior, and asymmetric gene expression in different species. Furthermore, their dysfunction is the cause of cyst formation in human kidney disease. This review focuses on the pros and cons of their candidacy as mechanically gated channels and on recent findings that have significantly advanced our physiological insight.
Medical subject headings
- Gene Expression Regulation
- Ion Channel Gating
- Mechanotransduction, Cellular
- Polycystic Kidney Diseases
- Proteins