The total synthesis of (-)-crispatene.
basic_science · Level V
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- Record sourced from PubMed, PMID 15273284.
- Also identified by PMC identifier 514427.
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Abstract
The total synthesis of the molluscan polypropionate (-)-crispatene is described. The synthesis features a palladium-catalyzed cross-coupling to establish a sensitive conjugated tetraene and its Lewis acid-catalyzed cycloisomerization to yield the bicyclo[3.1.0]hexene core of the natural product. The absolute configuration of (-)-crispatene and related molecules is established.
Medical subject headings
- Biological Products