Lamotrigine-induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy.
case_report · Level V
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Abstract
The authors describe a paradoxical reaction to lamotrigine (LTG) treatment in a patient with idiopathic rolandic epilepsy characterized by seizure deterioration, the appearance of new seizure type, and transient cognitive impairment. This phenomenon was present at a low dose after a slow titration and promptly reverted on LTG discontinuation. This rare event may have similarities with carbamazepine-induced seizure worsening caused by the Na++ channel inhibitory effect of the two antiepileptic drugs.
Medical subject headings
- Anticonvulsants
- Epilepsy, Rolandic
- Myoclonus
- Seizures
- Triazines