Efficient construction of the securine A carbon skeleton.
basic_science · Level V
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- Record sourced from PubMed, PMID 15280544.
- Also identified by PMC identifier 514433.
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Abstract
Securamine A is a structurally intriguing alkaloid possessing a pyrroloindole core joined via a modified isoprene subunit to a functionalized imidazole ring. Recent synthetic efforts in this laboratory have resulted in the efficient construction of key lactone 36, which undergoes tandem azide reduction/ring expansion to macrolactam 37. Macrolactam 37 possesses the complete macrocyclic core of securamine A.
Medical subject headings
- Indole Alkaloids