Urgently needed: a filter for the HIV-1 vaccine pipeline.

Moore, John P; Burton, Dennis R · Nat Med · 2004

expert_opinion · Level V

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Abstract

Research groups worldwide are trying to make immunogens intended to elicit neutralizing antibody responses as part of a prophylactic vaccine to counter the spread of HIV-1. The relative merits of different designs can only be gauged properly through comparative studies, and particularly by evaluating human or animal antisera under identical, or comparable, conditions. Hence there is a need for assay standardization and for the creation of a centralized testing facility that could distribute consensus protocols and reagents.

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