IL-5 links adaptive and natural immunity in reducing atherosclerotic disease.
review · Level V
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- Record sourced from PubMed, PMID 15286796.
- Also identified by PMC identifier 484989.
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Abstract
Oxidized LDL induces changes in several facets of the immune system, although the relationships between these facets and their contributions to atherogenesis have yet to be fully elucidated. A report in this issue of the JCI provides a novel demonstration of the adaptive immune system influencing the production of natural antibodies. The results demonstrate that injection of malondialdehyde-modified LDL promotes a Th2 response that in turn increases the titers of the natural antibody T15/EO6, which recognizes the oxidized phospholipid POVPC. Atherosclerotic lesion size in LDL receptor-deficient mice is reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the link between the adaptive and natural immune systems.
Medical subject headings
- Antibody Formation
- Arteriosclerosis
- Gene Expression Regulation
- Immunity, Innate
- Interleukin-5