Ribosomal movement impeded at a pseudoknot required for frameshifting.
basic_science · Level V
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- Record sourced from PubMed, PMID 1528874.
- Also identified by PMC identifier 49975.
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Abstract
Translational frameshifting sometimes occurs when ribosomes encounter a "shift" site preceding a region of unusual secondary structure, which in at least three cases is known to be a pseudoknot. We provide evidence that ribosomes have a decreased rate of movement through a pseudoknot required for frameshifting. These paused ribosomes are directly situated over the shift sequence. Ribosomal pausing appears to be necessary but not sufficient for frameshifting.
Medical subject headings
- Peptide Chain Elongation, Translational
- RNA, Messenger
- Ribosomes