A mechanical basis for chromosome function.

Kleckner, Nancy; Zickler, Denise; Jones, Gareth H; Dekker, Job; Padmore, Ruth; Henle, Jim; Hutchinson, John · Proc Natl Acad Sci U S A · 2004

basic_science · Level V

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Abstract

We propose that chromosome function is governed by internal mechanical forces generated by programmed tendencies for expansion of the DNA/chromatin fiber against constraining features.

Medical subject headings