Signal transduction at a protein synapse.
basic_science · Level V
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- Record sourced from PubMed, PMID 15315751.
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Abstract
Contraction of the bacteriophage T4 tail in the act of host cell penetration represents a massive structural change powered by conformational free energy. A paper in this issue of Cell by compares cryo-electron microscopic reconstructions of the initial and final states and reveals that the basic underlying mechanism is concerted rigid-body movements of the constituent protein subunits, akin to the tumbling of gears in a lock.
Medical subject headings
- Proteins
- Signal Transduction
- Synapses