Simulating genetic networks made easy: network construction with simple building blocks.
basic_science · Level V
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- Record sourced from PubMed, PMID 15319258.
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Abstract
We present SIM-plex, a genetic network simulator with a very intuitive interface in which a user can easily specify interactions as simple 'if-then' statements. The simulator is based on the mathematical model of Piecewise Linear Differential Equations (PLDEs). With PLDEs, genetic interactions are approximated as acting in a switch-like manner. The Java program, examples and a tutorial are available at http://www.psb.ugent.be/cbd/ {stcru,makui}@psb.ugent.be
Medical subject headings
- Algorithms
- Computer Simulation
- Gene Expression Regulation
- Models, Genetic
- Signal Transduction
- Transcription Factors
- User-Computer Interface