Phosphorylation regulates Id3 function in vascular smooth muscle cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 15321928.
- Also identified by PMC identifier 2929385.
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Abstract
Understanding the mechanisms that regulate cell cycle progression in vascular smooth muscle cells (VSMCs) is key to understanding and modulating vascular lesion formation. Results of the present study provide the first evidence that phosphorylation of the helix-loop-helix factor Id3 in VSMCs occurs in vitro and in vivo and provides a regulatory switch controlling Id3-induced regulation of p21Cip1 and VSMC growth.
Medical subject headings
- Myocytes, Smooth Muscle
- Protein Processing, Post-Translational
- Proteins
- Transcription Factors