Autosomal dominant palmoplantar hyperkeratosis and sensorineural deafness in three generations.

Sharland, M; Bleach, N R; Goberdhan, P D; Patton, M A · J Med Genet · 1992

case_report · Level V

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Abstract

A family is presented with autosomal dominant progressive palmoplantar hyperkeratosis, which is invariably associated with a slowly progressive, bilateral, high frequency, sensorineural hearing loss. The family show no other ectodermal abnormality. The differential diagnosis and possible mechanisms are discussed. This family appears to represent a unique variant in the hyperkeratosis-deafness association.

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