Intercontinental spread of pyrimethamine-resistant malaria.
Where this comes from
- Record sourced from PubMed, PMID 15326348.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis.
Medical subject headings
- Antimalarials
- Malaria, Falciparum
- Mutation
- Plasmodium falciparum
- Pyrimethamine
- Tetrahydrofolate Dehydrogenase