Sculpting heart valves with NFATc and VEGF.
review · Level V
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Abstract
Heart valves are of vital importance for our moment-to-moment existence, but how they form remains a mystery. In this issue of Cell, Chang et al. reveal a novel role for calcineurin, NFATs, and VEGF in valve formation. Dynamic changes in NFAT/VEGF expression in regional myocardial and endocardial fields and developmental windows orchestrate this complex process.
Medical subject headings
- Calcineurin
- DNA-Binding Proteins
- Heart Valves
- Nuclear Proteins
- Transcription Factors
- Vascular Endothelial Growth Factor A