The lingering enigma of the allelic exclusion mechanism.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 15339659.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
B lymphocytes produce diverse antibody specificities by "randomly" assembling antibody genes from germline segments. Yet, though each B lymphocyte has multiple allelic loci for the different antibody chains, each clonally derived mature B lymphocyte expresses a single species of antibody with a unique specificity via a process termed allelic exclusion. Despite some progress, the precise mechanism of allelic exclusion remains an enigma.
Medical subject headings
- Alleles
- Antibodies
- Antibody Specificity
- B-Lymphocytes