Gene-promoter hypermethylation as a biomarker in lung cancer.
review · Level V
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Abstract
Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial component in cancer initiation and progression. Highly sensitive assays have been developed to assess gene-promoter methylation in biological fluids. The detection of methylated genes in sputum could lead to the development of a screening test to non-invasively identify early cancer in high-risk people.
Medical subject headings
- Biomarkers, Tumor
- DNA Methylation
- Gene Silencing
- Lung Neoplasms
- Promoter Regions, Genetic