Proto-oncogene expression in rabbit aorta after wall injury. First marker of the cellular process leading to restenosis after angioplasty?
basic_science · Level V
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Abstract
In order to study the earliest phenomenons occurring in the arterial wall after balloon angioplasty, the level of expression of the proto-oncogenes, c-fos and c-myc, was studied in rabbit aorta after balloon denudation by using Northern blot analysis. Both c-fos and c-myc are rapidly and transitorily induced (maximal at 30 min and 2 h after mechanical injury for c-fos and c-myc respectively). By comparison, infusion of norepinephrine increases oncogene expression in normal non-denuded rabbit aorta after 1 h, but the combination of both mechanical and hormonal stimuli do not lead to a more important induction than balloon denudation alone.
Medical subject headings
- Angioplasty, Balloon
- Cell Division
- Fibromuscular Dysplasia
- Gene Expression Regulation
- Muscle, Smooth, Vascular
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-myc