K103N mutation in antiretroviral therapy-naive African patients infected with HIV type 1.
case_report · Level V
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Abstract
Most of the information about genetic sequencing and drug susceptibility of human immunodeficiency virus type 1 (HIV-1) is derived from the study of HIV-1 subtype B. Worldwide, most people infected with HIV-1 are infected with non-subtype B viruses and live in developing countries. We report 3 cases of antiretroviral-naive African immigrants infected with HIV-1 strains possessing the K103N mutation in the reverse transcriptase gene, which confers high-level resistance to all nonnucleoside reverse transcriptase inhibitors.
Medical subject headings
- Antiretroviral Therapy, Highly Active
- Asparagine
- Drug Resistance, Viral
- HIV Infections
- HIV-1
- Lysine
- Mutation, Missense