Stevens-Johnson syndrome after immunization with smallpox, anthrax, and tetanus vaccines.

Chopra, Ashish; Drage, Lisa A; Hanson, Eric M; Touchet, Nicole L · Mayo Clin Proc · 2004

case_report · Level V

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Abstract

A 19-year-old male military recruit developed erythema multiforme 20 days after receiving a triad of vaccinations: smallpox (vaccinia virus), anthrax, and tetanus. Over the course of a few days, the erythema multiforme evolved into Stevens-Johnson syndrome, associated with widespread bullae, stomatitis, conjunctivitis, and fever. After 7 days of conservative management, the patient's signs and symptoms improved. This case serves as a timely reminder of a severe and potentially life-threatening complication of smallpox vaccination.

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