Malignant hyperthermia. An historical vignette.

Harrison, G G; Isaacs, H · Anaesthesia · 1992

other · Level V

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Abstract

This paper reports previously unpublished accounts of the deaths in 1915 and 1919 of two members of the same family during general anaesthesia. The deaths were subsequently ascribed to a 'hereditary susceptibility' to chloroform. Contemporary evidence is presented which suggests that these deaths were among the very earliest examples of malignant hyperthermia to be described.

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