APOE-dependent PET patterns of brain activation in Alzheimer disease.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 15365149.
- Also identified by PMC identifier 3026570.
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Abstract
Using H2(15)O PET, the authors imaged 13 patients with Alzheimer disease (AD) while performing a serial nonverbal recognition memory task. Patterns of brain activation differed as a function of APOE genotype: epsilon4 carriers exhibited lower activation in the left lingual gyrus and higher activation in left cuneus, precuneus, parahippocampal, and right precentral gyrus. The APOE genotype seems to play a role in cerebral physiologic activity even after onset of clinical manifestations of AD.
Medical subject headings
- Alzheimer Disease
- Apolipoproteins E
- Brain
- Brain Mapping
- Positron-Emission Tomography